Note: This is an export from my old wordpress website, your comments or references might be lost during the migration. Sorry for the inconvenience. download lastz wget http://www.bx.psu.edu/miller_lab/dist/lastz-1.02.00.tar.gz mv lastz-1.02.00.tar.gz ~/Software/src tar zxfv lastz-1.02.00.tar.gz cd lastz-distrib-1.02.00 edit install path vim make-include.mak # change installDir like this : installDir = ${HOME}/Software/bin install lastz cd src make make install troubleshooting In case of the following error occurred, segment.c:1330:10: error: comparison of array 'st->seg' equal to a null pointer is always false [-Werror,-Wtautological-pointer-compare] if (st->seg == NULL) return; ~~~~^~~ ~~~~ 1 error generated. make: *** [segment.o] Error 1 just remove -Werror in the Makefile at this line: definedForAll = -Wall -Wextra -Werror -D_FILE_OFFSET_BITS=64 -D_LARGEFILE_SOURCE